InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NISCH

Summary

InnateDB Gene

IDBG-39046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NISCH

Gene Name

nischarin

Synonyms

hIRAS; I-1; IR1; IRAS

Species

Homo sapiens

Ensembl Gene

ENSG00000010322

Encoded Proteins

IDBP-39048

nischarin

IDBP-379331

nischarin

IDBP-483494

nischarin

IDBP-478470

nischarin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:52455118-52493071

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000345716	ENSP00000339958
ENST00000420808	ENSP00000392484
ENST00000479054	ENSP00000418232
ENST00000488380	ENSP00000417812
ENST00000489895
ENST00000488157
ENST00000490425
ENST00000464280
ENST00000481211
ENST00000474188
ENST00000485765
ENST00000460759
ENST00000488243
ENST00000467594

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008227	G-protein coupled amine receptor activity
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0048243	norepinephrine secretion

Cellular Component

GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0055037	recycling endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021910

View Gene Order

ENSBTAG00000014779

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435290 Hs.629379 Hs.662535

RefSeq

NM_001276293 NM_001276294 NM_007184

HUGO

OMIM

CCDS

CCDS33767 CCDS63651 CCDS63652

HPRD

11391

IMGT

EMBL

GenPept

RNA Seq Atlas