Version 5.4
Mus musculus Gene: Nisch
Summary
InnateDB Gene IDBG-145371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nisch
Gene Name nischarin
Synonyms 1200007D05Rik; 3202002H23Rik; AW494485; I-1
Species Mus musculus
Ensembl Gene ENSMUSG00000021910
Encoded Proteins
IDBP-145373
nischarin
IDBP-624607
nischarin
IDBP-624638
nischarin
IDBP-624639
nischarin
IDBP-624640
nischarin
IDBP-624642
nischarin
IDBP-624643
nischarin
IDBP-624646
nischarin
IDBP-624649
nischarin
IDBP-624652
nischarin
IDBP-624654
nischarin
IDBP-624658
nischarin
IDBP-624660
nischarin
IDBP-624664
nischarin
IDBP-624668
nischarin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010322:
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:31170930-31216946
Strand Reverse strand
Band B
Transcripts
ENSMUST00000022469 ENSMUSP00000022469
ENSMUST00000168206 ENSMUSP00000132842
ENSMUST00000170253 ENSMUSP00000129547
ENSMUST00000169628 ENSMUSP00000131465
ENSMUST00000167449 ENSMUSP00000126001
ENSMUST00000163552 ENSMUSP00000131689
ENSMUST00000168451 ENSMUSP00000132912
ENSMUST00000169906 ENSMUSP00000129268
ENSMUST00000170436 ENSMUSP00000131861
ENSMUST00000164956
ENSMUST00000163846
ENSMUST00000167223
ENSMUST00000172142 ENSMUSP00000132413
ENSMUST00000164000
ENSMUST00000170343 ENSMUSP00000130246
ENSMUST00000165981 ENSMUSP00000130210
ENSMUST00000164989 ENSMUSP00000126982
ENSMUST00000167979
ENSMUST00000169149 ENSMUSP00000131623
ENSMUST00000172370
ENSMUST00000164617
ENSMUST00000171735 ENSMUSP00000127132
ENSMUST00000167602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008227 G-protein coupled amine receptor activity
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006915 apoptotic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048243 norepinephrine secretion
Cellular Component
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000010322
View Gene Order
ENSBTAG00000014779
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.298728 Mm.401055 Mm.475576
RefSeq NM_022656 XM_006519354
OMIM
CCDS CCDS36853
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca