InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A6

Summary

InnateDB Gene

IDBG-39774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A6

Gene Name

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Synonyms

2; 3; AAC3; ANT; ANT 2; ANT 3; ANT3; ANT3Y

Species

Homo sapiens

Ensembl Gene

ENSG00000169100

Encoded Proteins

IDBP-39776

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2009]
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:1386152-1392724

Strand

Reverse strand

Band

p22.33

Transcripts

ENST00000381401	ENSP00000370808
ENST00000475167
ENST00000484026

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.

Experimentally validated
Total	97 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005471	ATP:ADP antiporter activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006626	protein targeting to mitochondrion
GO:0006915	apoptotic process
GO:0015866	ADP transport
GO:0015867	ATP transport
GO:0016032	viral process
GO:0019048	modulation by virus of host morphology or physiology
GO:0019058	viral life cycle
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0046732	active induction of host immune response by virus
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0016021	integral component of membrane