InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A6

Summary

InnateDB Protein

IDBP-39776.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A6

Protein Name

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Synonyms

2; 3; AAC3; ANT; ANT 2; ANT 3; ANT3; ANT3Y;

Species

Homo sapiens

Ensembl Protein

ENSP00000370808

InnateDB Gene

IDBG-39774 (SLC25A6)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269PubMed:15033708}.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.

Experimentally validated
Total	97 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005471	ATP:ADP antiporter activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006626	protein targeting to mitochondrion
GO:0006915	apoptotic process
GO:0015866	ADP transport
GO:0015867	ATP transport
GO:0016032	viral process
GO:0019048	modulation by virus of host morphology or physiology
GO:0019058	viral life cycle
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0046732	active induction of host immune response by virus
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002030 Mitochondrial brown fat uncoupling protein
IPR002067 Mitochondrial carrier protein
IPR002113 Adenine nucleotide translocator 1
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00784
PR00926
PR00927

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P12236