Version 5.4
Homo sapiens Gene: NSFL1C
Summary
InnateDB Gene IDBG-39809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSFL1C
Gene Name NSFL1 (p97) cofactor (p47)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088833
Encoded Proteins
IDBP-598292
NSFL1 (p97) cofactor (p47)
IDBP-39817
NSFL1 (p97) cofactor (p47)
IDBP-39819
NSFL1 (p97) cofactor (p47)
IDBP-478918
NSFL1 (p97) cofactor (p47)
IDBP-810794
NSFL1 (p97) cofactor (p47)
IDBP-810795
NSFL1 (p97) cofactor (p47)
IDBP-600030
NSFL1 (p97) cofactor (p47)
IDBP-598641
NSFL1 (p97) cofactor (p47)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:1442162-1473842
Strand Reverse strand
Band p13
Transcripts
ENST00000381653 ENSP00000434067
ENST00000216879 ENSP00000216879
ENST00000353088 ENSP00000338643
ENST00000461211
ENST00000476071 ENSP00000418529
ENST00000470376 ENSP00000473400
ENST00000489203 ENSP00000473616
ENST00000487086
ENST00000478168
ENST00000555944 ENSP00000452019
ENST00000555568 ENSP00000451675
ENST00000555359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027455
View Gene Order
ENSBTAG00000006533
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9UNZ2
TrEMBL G3V4V8
UniProt Splice Variant
Entrez Gene 55968
UniGene Hs.598664 Hs.622160
RefSeq NM_001206736 XM_006723591 NM_016143 NM_018839 XM_006723592 XM_006723593 XM_006723594
HUGO HGNC:15912
OMIM 606610
CCDS CCDS56175 CCDS13015 CCDS13016
HPRD 09425
IMGT
EMBL AF078856 AF086909 AF112211 AK001511 AK297403 AK315433 AL109658 BC002801 CH471133
GenPept AAD44488 AAF17199 AAH02801 AAP97139 BAA91731 BAG37821 BAG59842 CAB96827 CAI22730 CAI22731 CAM28306 EAX10629 EAX10631
RNA Seq Atlas 55968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca