Version 5.4
Homo sapiens Protein: NSFL1C
Summary
InnateDB Protein IDBP-478918.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSFL1C
Protein Name NSFL1 (p97) cofactor (p47)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418529
InnateDB Gene IDBG-39809 (NSFL1C)
Protein Structure
UniProt Annotation
Function Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Chromosome {ECO:0000250}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001012 UBX domain
IPR009060 UBA-like
IPR012989 SEP domain
IPR029071 Ubiquitin-related domain
PFAM PF00789
PF08059
PRINTS
PIRSF
SMART SM00166
SM00553
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UNZ2
PhosphoSite PhosphoSite-Q9UNZ2
TrEMBL G3V4V8
UniProt Splice Variant
Entrez Gene 55968
UniGene Hs.622160
RefSeq NP_001193665
HUGO HGNC:15912
OMIM 606610
CCDS CCDS56175
HPRD 09425
IMGT
EMBL AF078856 AF086909 AF112211 AK001511 AK297403 AK315433 AL109658 BC002801 CH471133
GenPept AAD44488 AAF17199 AAH02801 AAP97139 BAA91731 BAG37821 BAG59842 CAB96827 CAI22730 CAI22731 CAM28306 EAX10629 EAX10631

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca