Homo sapiens Gene: DDX19B
Summary
InnateDB Gene IDBG-39886.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX19B
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Synonyms DBP5; DDX19; RNAh
Species Homo sapiens
Ensembl Gene ENSG00000157349
Encoded Proteins
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
DEAD (Asp-Glu-Ala-As) box polypeptide 19B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70289663-70335283
Strand Forward strand
Band q22.1
Transcripts
ENST00000288071 ENSP00000288071
ENST00000355992 ENSP00000348271
ENST00000393657 ENSP00000377267
ENST00000451014 ENSP00000392639
ENST00000570055
ENST00000563392 ENSP00000456574
ENST00000568408 ENSP00000457366
ENST00000566216 ENSP00000454495
ENST00000562519 ENSP00000455193
ENST00000568008 ENSP00000454571
ENST00000569224
ENST00000563206 ENSP00000455813
ENST00000568625 ENSP00000456757
ENST00000569099
ENST00000568460 ENSP00000457633
ENST00000562912 ENSP00000459407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0008152 metabolic process
GO:0015031 protein transport
Cellular Component
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.221761 Hs.733081
RefSeq NM_001014449 NM_001014451 NM_001257172 NM_001257173 NM_001257174 NM_001257175 NM_007242 XM_006721126 XM_006721127
HUGO
OMIM
CCDS CCDS10888 CCDS32475 CCDS42187 CCDS58478
HPRD 05781
IMGT
EMBL
GenPept
RNA Seq Atlas