InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX19B

Summary

InnateDB Protein

IDBP-243157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX19B

Protein Name

DEAD (Asp-Glu-Ala-As) box polypeptide 19B

Synonyms

DBP5; DDX19; RNAh;

Species

Homo sapiens

Ensembl Protein

ENSP00000377267

InnateDB Gene

IDBG-39886 (DDX19B)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Subcellular Localization

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0006406	mRNA export from nucleus
GO:0015031	protein transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UMR2