Version 5.4
Homo sapiens Gene: FLNC
Summary
InnateDB Gene IDBG-40116.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLNC
Gene Name filamin C, gamma
Synonyms ABP-280; ABP280A; ABPA; ABPL; FLN2; MFM5; MPD4
Species Homo sapiens
Ensembl Gene ENSG00000128591
Encoded Proteins
IDBP-40118
filamin C, gamma
IDBP-40120
filamin C, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128830377-128859274
Strand Forward strand
Band q32.1
Transcripts
ENST00000325888 ENSP00000327145
ENST00000346177 ENSP00000344002
ENST00000388853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0030506 ankyrin binding
Biological Process
GO:0034329 cell junction assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016528 sarcoplasm
GO:0030018 Z disc
GO:0042383 sarcolemma
GO:0043034 costamere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068699
View Gene Order
ENSBTAG00000006253
Not yet available
Pathways
NETPATH
REACTOME
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
Cross-References
SwissProt Q14315
TrEMBL B3KM41 Q59H94
UniProt Splice Variant
Entrez Gene 2318
UniGene Hs.58414
RefSeq NM_001127487 NM_001458
HUGO HGNC:3756
OMIM 102565
CCDS CCDS43644 CCDS47705
HPRD
IMGT
EMBL AB208865 AB371585 AC025594 AF089841 AF146692 AF184119 AF184120 AF184121 AF184122 AF184123 AF184124 AF184125 AF184126 AF252549 AJ012737 AJ132990 AK001048 CH471070 X70083 X70084
GenPept AAD12245 AAF67190 AAF68195 AAF80245 BAD92102 BAG48314 BAG50853 CAA49688 CAA49689 CAB46442 CAB51535 EAW83691
RNA Seq Atlas 2318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca