InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Flnc

Summary

InnateDB Gene

IDBG-131332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flnc

Gene Name

filamin C, gamma

Synonyms

1110055E19Rik; ABP-280; ABPL; Fln2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068699

Encoded Proteins

IDBP-131334

filamin C, gamma

IDBP-131336

filamin C, gamma

IDBP-131338

filamin C, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128591:
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:29433153-29461888

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000065090	ENSMUSP00000064163
ENSMUST00000090474	ENSMUSP00000087960
ENSMUST00000101617	ENSMUSP00000099139
ENSMUST00000148404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030506	ankyrin binding

Biological Process

GO:0030029	actin filament-based process
GO:0048747	muscle fiber development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016528	sarcoplasm
GO:0030018	Z disc
GO:0042383	sarcolemma

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000128591

View Gene Order

ENSBTAG00000006253

Not yet available

Pathways

NETPATH

REACTOME

REACT_243772

Cell-extracellular matrix interactions pathway

REACT_241978

Cell junction organization pathway

REACT_223082

Cell-Cell communication pathway

KEGG

mmu04010

MAPK signaling pathway pathway

mmu04510

Focal adhesion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20649

Cell-extracellular matrix interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D3Z576

UniProt Splice Variant

Entrez Gene

68794

UniGene

Mm.39046

RefSeq

NM_001081185 XM_006505164

OMIM

CCDS

CCDS39452

HPRD

IMGT

MGI ID

MGI:95557

MGI Symbol

Flnc

EMBL

AC044807

GenPept

RNA Seq Atlas

68794