Version 5.4
Homo sapiens Gene: EIF6
Summary
InnateDB Gene IDBG-402142.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF6
Gene Name eukaryotic translation initiation factor 6
Synonyms b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP; p27(BBP); p27BBP
Species Homo sapiens
Ensembl Gene ENSG00000242372
Encoded Proteins
IDBP-69540
eukaryotic translation initiation factor 6
IDBP-69542
eukaryotic translation initiation factor 6
IDBP-69544
eukaryotic translation initiation factor 6
IDBP-372742
eukaryotic translation initiation factor 6
IDBP-372756
eukaryotic translation initiation factor 6
IDBP-372757
eukaryotic translation initiation factor 6
IDBP-372759
eukaryotic translation initiation factor 6
IDBP-810615
eukaryotic translation initiation factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35278907-35284985
Strand Reverse strand
Band q11.22
Transcripts
ENST00000374450 ENSP00000363574
ENST00000374443 ENSP00000363566
ENST00000374436 ENSP00000363559
ENST00000440766 ENSP00000395907
ENST00000447927 ENSP00000411450
ENST00000415116 ENSP00000415044
ENST00000456600 ENSP00000390897
ENST00000462894
ENST00000621148 ENSP00000483289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 125 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006413 translational initiation
GO:0042256 mature ribosome assembly
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005638 lamin filament
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027613
View Gene Order
ENSBTAG00000011263
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001267810 NM_002212 NM_181466 NM_181468
HUGO
OMIM
CCDS CCDS13249 CCDS13250
HPRD 04221
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca