Version 5.4
Bos taurus Gene: EIF6
Summary
InnateDB Gene IDBG-642148.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF6
Gene Name Eukaryotic translation initiation factor 6
Synonyms ITGB4BP
Species Bos taurus
Ensembl Gene ENSBTAG00000011263
Encoded Proteins
IDBP-694573
Eukaryotic translation initiation factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242372:
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:65206238-65212123
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014966 ENSBTAP00000014966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.
Predicted by orthology
Total 134 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006412 translation
GO:0006413 translational initiation
GO:0042256 mature ribosome assembly
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005638 lamin filament
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000027613
View Gene Order
ENSG00000242372
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9TU47
TrEMBL
UniProt Splice Variant
Entrez Gene 286811
UniGene Bt.4426
RefSeq NM_174830 XM_005214503
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF141872 BC109922
GenPept AAF00595 AAI09923
RNA Seq Atlas 286811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca