Version 5.4
Homo sapiens Gene: ARHGDIG
Summary
InnateDB Gene IDBG-402162.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGDIG
Gene Name Rho GDP dissociation inhibitor (GDI) gamma
Synonyms RHOGDI-3
Species Homo sapiens
Ensembl Gene ENSG00000242173
Encoded Proteins
IDBP-7352
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-361301
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-361303
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-361306
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-361316
Rho GDP dissociation inhibitor (GDI) gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:268727-283010
Strand Forward strand
Band p13.3
Transcripts
ENST00000219409 ENSP00000219409
ENST00000412541 ENSP00000408037
ENST00000435035 ENSP00000397395
ENST00000447871 ENSP00000404435
ENST00000414650 ENSP00000410541
ENST00000464609
ENST00000477621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0032880 regulation of protein localization
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073433
View Gene Order
ENSBTAG00000027854
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001176
HUGO
OMIM
CCDS CCDS10404
HPRD 04163
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca