Version 5.4
Mus musculus Gene: Arhgdig
Summary
InnateDB Gene IDBG-154871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgdig
Gene Name Rho GDP dissociation inhibitor (GDI) gamma
Synonyms Gdi5; Rho-GDI-3; Rho-GDI2; RIP2
Species Mus musculus
Ensembl Gene ENSMUSG00000073433
Encoded Proteins
IDBP-154873
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-401404
Rho GDP dissociation inhibitor (GDI) gamma
IDBP-714850
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242173:
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:26196226-26207786
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000025019 ENSMUSP00000025019
ENSMUST00000121959 ENSMUSP00000113186
ENSMUST00000155556
ENSMUST00000176961 ENSMUSP00000135717
ENSMUST00000176847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032880 regulation of protein localization
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000242173
View Gene Order
ENSBTAG00000027854
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04722
Neurotrophin signaling pathway pathway
mmu04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt Q62160
TrEMBL D3Z6W0 Q3UNB6
UniProt Splice Variant
Entrez Gene 14570
UniGene
RefSeq NM_008113
OMIM
CCDS CCDS28548
HPRD
IMGT
MGI ID MGI:108430
MGI Symbol Arhgdig
EMBL AC126438 AK144321 BC002032 BC158003 CH466606 L42463 U73198
GenPept AAB18196 AAC37704 AAH02032 AAI58004 BAE25831 EDL22493
RNA Seq Atlas 14570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca