Homo sapiens Gene: STRC

Summary
InnateDB Gene IDBG-402174.2
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol STRC
Gene Name stereocilin
Synonyms DFNB16
Species Homo sapiens
Ensembl Gene ENSG00000242866
Encoded Proteins
IDBP-370373 stereocilin
IDBP-370397 stereocilin
IDBP-370401 stereocilin
IDBP-370404 stereocilin
IDBP-370405 stereocilin
IDBP-598275 stereocilin
Entrez Gene
Summary This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 43891596-44010458
Strand Reverse strand
Band q15.3
Transcripts
ENST00000450892  ENSP00000401513
ENST00000428650  ENSP00000415991
ENST00000440125  ENSP00000394866
ENST00000455136  ENSP00000394755
ENST00000432436  ENSP00000407303
ENST00000448437 
ENST00000471703 
ENST00000485556 
ENST00000460952 
ENST00000493750 
ENST00000483250 
ENST00000470279 
ENST00000541030  ENSP00000440413
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
Biological Process
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060088 auditory receptor cell stereocilium organization
Cellular Component
GO:0009986 cell surface
GO:0032420 stereocilium
GO:0032426 stereocilium bundle tip
GO:0060091 kinocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000033498 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000007503 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7RTU9 
TrEMBL E7EPM8 E9PBT5 F5GXA4 H7C2Q6
UniProt Splice Variant
Entrez Gene 161497 
UniGene Hs.657395
RefSeq NM_153700 
HUGO 16035 
OMIM 606440
CCDS CCDS10098 
HPRD 08403
IMGT
EMBL AC011330 AC018512 BK000138
GenPept DAA00085 
ImmGen STRC (murine) 
RNA Seq Atlas 161497