Version 5.4
Homo sapiens Protein: STRC
Summary
InnateDB Protein IDBP-370373.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STRC
Protein Name stereocilin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000401513
InnateDB Gene IDBG-402174 (STRC)
Protein Structure
UniProt Annotation
Function Essential to the formation of horizontal top connectors between outer hair cell stereocilia. {ECO:0000250}.
Subcellular Localization Cell surface {ECO:0000250}. Cell projection, kinocilium {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.
Disease Associations Deafness, autosomal recessive, 16 (DFNB16) [MIM:603720]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:11687802}. Note=The disease is caused by mutations affecting the gene represented in this entry.Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. {ECO:0000269PubMed:17098888}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060088 auditory receptor cell stereocilium organization
Cellular Component
GO:0009986 cell surface
GO:0032420 stereocilium
GO:0032426 stereocilium bundle tip
GO:0060091 kinocilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTU9
PhosphoSite PhosphoSite-Q7RTU9
TrEMBL E7EPM8
UniProt Splice Variant
Entrez Gene 161497
UniGene Hs.657395
RefSeq NP_714544
HUGO HGNC:16035
OMIM 606440
CCDS CCDS10098
HPRD 08403
IMGT
EMBL AC011330 AC018512 BK000138
GenPept DAA00085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca