Version 5.4
Homo sapiens Gene: APOBEC3C
Summary
InnateDB Gene IDBG-402340.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3C
Gene Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000244509
Encoded Proteins
IDBP-7933
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
IDBP-377029
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39014083-39020352
Strand Forward strand
Band q13.1
Transcripts
ENST00000361441 ENSP00000355340
ENST00000428892 ENSP00000390855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0044822 poly(A) RNA binding
Biological Process
GO:0009972 cytidine deamination
GO:0010529 negative regulation of transposition
GO:0016032 viral process
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL F8WB92
UniProt Splice Variant
Entrez Gene 27350
UniGene
RefSeq NM_014508
HUGO HGNC:17353
OMIM 607750
CCDS CCDS13983
HPRD 09671
IMGT
EMBL AL022318
GenPept
RNA Seq Atlas 27350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca