Version 5.4
Homo sapiens Gene: HSD17B12
Summary
InnateDB Gene IDBG-40501.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B12
Gene Name hydroxysteroid (17-beta) dehydrogenase 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149084
Encoded Proteins
IDBP-40503
hydroxysteroid (17-beta) dehydrogenase 12
IDBP-239017
hydroxysteroid (17-beta) dehydrogenase 12
IDBP-586948
hydroxysteroid (17-beta) dehydrogenase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:43556436-43856617
Strand Forward strand
Band p11.2
Transcripts
ENST00000278353 ENSP00000278353
ENST00000395700 ENSP00000379052
ENST00000526615
ENST00000532864
ENST00000533358
ENST00000529261
ENST00000532989
ENST00000527433
ENST00000531185 ENSP00000436582
ENST00000527213
ENST00000532178
ENST00000533090
ENST00000533802
ENST00000534053
ENST00000525736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019432 triglyceride biosynthetic process
GO:0030198 extracellular matrix organization
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027195
View Gene Order
ENSBTAG00000000087
Not yet available
Pathways
NETPATH
REACTOME
REACT_11059
Androgen biosynthesis pathway
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00062
Fatty acid elongation pathway
hsa00140
Steroid hormone biosynthesis pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.132513
RefSeq NM_016142
HUGO
OMIM
CCDS CCDS7905
HPRD 09989
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca