Version 5.4
Bos taurus Gene: LOC789567
Summary
InnateDB Gene IDBG-636859.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOC789567
Gene Name estradiol 17-beta-dehydrogenase 12
Synonyms KAR
Species Bos taurus
Ensembl Gene ENSBTAG00000000087
Encoded Proteins
IDBP-688835
hypothetical protein LOC789567
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149084:
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74652043-74830690
Strand Forward strand
Band
Transcripts
ENSBTAT00000000096 ENSBTAP00000000096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0008152 metabolic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000149084
View Gene Order
ENSMUSG00000027195
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11059
Androgen biosynthesis pathway
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_252780
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_255695
Fatty Acyl-CoA Biosynthesis pathway
REACT_237947
Triglyceride Biosynthesis pathway
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00062
Fatty acid elongation pathway
hsa00140
Steroid hormone biosynthesis pathway
mmu01040
Biosynthesis of unsaturated fatty acids pathway
mmu00062
Fatty acid elongation pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A6H7H3
UniProt Splice Variant
Entrez Gene 789567
UniGene Bt.104048 Bt.110824 Bt.69974 Bt.89260
RefSeq NM_001101307
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146246 DAAA02041494 DAAA02041495 DAAA02041496 DAAA02041497 DAAA02041498 DAAA02041499
GenPept AAI46247
RNA Seq Atlas 789567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca