Version 5.4
Homo sapiens Gene: SIRPG
Summary
InnateDB Gene IDBG-40567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRPG
Gene Name signal-regulatory protein gamma
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089012
Encoded Proteins
IDBP-40569
signal-regulatory protein gamma
IDBP-40571
signal-regulatory protein gamma
IDBP-40573
signal-regulatory protein gamma
IDBP-40575
signal-regulatory protein gamma
IDBP-40579
signal-regulatory protein gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:1629152-1657779
Strand Reverse strand
Band p13
Transcripts
ENST00000303415 ENSP00000305529
ENST00000216927 ENSP00000216927
ENST00000381583 ENSP00000370995
ENST00000344103 ENSP00000342759
ENST00000381580 ENSP00000370992
ENST00000478145
ENST00000497407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0022409 positive regulation of cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_604
Hemostasis pathway
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001039508 NM_018556 NM_080816
HUGO
OMIM
CCDS CCDS13020 CCDS13021 CCDS33434
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca