InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRPG

Summary

InnateDB Protein

IDBP-40569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRPG

Protein Name

signal-regulatory protein gamma

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305529

InnateDB Gene

IDBG-40567 (SIRPG)

Protein Structure

UniProt Annotation

Function

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269PubMed:15383453}.

Subcellular Localization

Membrane {ECO:0000269PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269PubMed:15383453}.

Disease Associations

Tissue Specificity

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. {ECO:0000269PubMed:11185750, ECO:0000269PubMed:15383453}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0022409	positive regulation of cell-cell adhesion
GO:0035556	intracellular signal transduction
GO:0050870	positive regulation of T cell activation
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P1W8