InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL7

Summary

InnateDB Gene

IDBG-40580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL7

Gene Name

chemokine (C-C motif) ligand 7

Synonyms

FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7

Species

Homo sapiens

Ensembl Gene

ENSG00000108688

Encoded Proteins

IDBP-40582

chemokine (C-C motif) ligand 7

IDBP-241213

chemokine (C-C motif) ligand 7

IDBP-241215

chemokine (C-C motif) ligand 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34270221-34272242

Strand

Forward strand

Band

q12

Transcripts

ENST00000378569	ENSP00000367832
ENST00000394630	ENSP00000378126
ENST00000394627	ENSP00000378124

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	19 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0031726	CCR1 chemokine receptor binding
GO:0031727	CCR2 chemokine receptor binding

Biological Process

GO:0002548	monocyte chemotaxis
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0010332	response to gamma radiation
GO:0030335	positive regulation of cell migration
GO:0048245	eosinophil chemotaxis
GO:0060326	cell chemotaxis
GO:0071361	cellular response to ethanol
GO:2000503	positive regulation of natural killer cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P80098

TrEMBL

A8MVH1 A8MX17 Q7Z7Q8

UniProt Splice Variant

Entrez Gene

6354

UniGene

RefSeq

NM_006273

HUGO

HGNC:10634

OMIM

158106

CCDS

CCDS11278

HPRD

IMGT

EMBL

AC005549 AF043338 BC092436 BC112258 BC112260 CH471147 X71087 X72308 X72309

GenPept

AAC03538 AAH92436 AAI12259 AAI12261 CAA50405 CAA50406 CAA50407 CAA51055 CAB59723 EAW80210

RNA Seq Atlas

6354