InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL7

Summary

InnateDB Protein

IDBP-40582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL7

Protein Name

chemokine (C-C motif) ligand 7

Synonyms

FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7;

Species

Homo sapiens

Ensembl Protein

ENSP00000367832

InnateDB Gene

IDBG-40580 (CCL7)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	19 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0031726	CCR1 chemokine receptor binding
GO:0031727	CCR2 chemokine receptor binding

Biological Process

GO:0002548	monocyte chemotaxis
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0010332	response to gamma radiation
GO:0030335	positive regulation of cell migration
GO:0048245	eosinophil chemotaxis
GO:0060326	cell chemotaxis
GO:0071361	cellular response to ethanol
GO:2000503	positive regulation of natural killer cell chemotaxis