InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL11

Summary

InnateDB Gene

IDBG-40645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL11

Gene Name

chemokine (C-C motif) ligand 11

Synonyms

SCYA11

Species

Homo sapiens

Ensembl Gene

ENSG00000172156

Encoded Proteins

IDBP-40647

chemokine (C-C motif) ligand 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34285668-34288334

Strand

Forward strand

Band

q12

Transcripts

ENST00000305869

ENSP00000302234

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	15 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002544	chronic inflammatory response
GO:0002551	mast cell chemotaxis
GO:0006468	protein phosphorylation
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008360	regulation of cell shape
GO:0009314	response to radiation
GO:0009615	response to virus
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0048245	eosinophil chemotaxis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070371	ERK1 and ERK2 cascade
GO:0070670	response to interleukin-4