InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL11

Summary

InnateDB Protein

IDBP-40647.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL11

Protein Name

chemokine (C-C motif) ligand 11

Synonyms

SCYA11;

Species

Homo sapiens

Ensembl Protein

ENSP00000302234

InnateDB Gene

IDBG-40645 (CCL11)

Protein Structure

UniProt Annotation

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	15 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002544	chronic inflammatory response
GO:0002551	mast cell chemotaxis
GO:0006468	protein phosphorylation
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008360	regulation of cell shape
GO:0009314	response to radiation
GO:0009615	response to virus
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0048245	eosinophil chemotaxis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070371	ERK1 and ERK2 cascade
GO:0070670	response to interleukin-4