InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL8

Summary

InnateDB Gene

IDBG-40686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL8

Gene Name

chemokine (C-C motif) ligand 8

Synonyms

HC14; MCP-2; MCP2; SCYA10; SCYA8

Species

Homo sapiens

Ensembl Gene

ENSG00000108700

Encoded Proteins

IDBP-241225

chemokine (C-C motif) ligand 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34319036-34321402

Strand

Forward strand

Band

q12

Transcripts

ENST00000394620

ENSP00000378118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0016004	phospholipase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006887	exocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009615	response to virus
GO:0043085	positive regulation of catalytic activity
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P80075

TrEMBL

H0UIC7

UniProt Splice Variant

Entrez Gene

6355

UniGene

Hs.271387 Hs.713001

RefSeq

NM_005623

HUGO

HGNC:10635

OMIM

602283

CCDS

CCDS11280

HPRD

03791

IMGT

EMBL

BC126242 CH471147 X99886 Y10802 Y16645

GenPept

AAI26243 CAA68168 CAA71760 CAA76341 EAW80207 EAW80208

RNA Seq Atlas

6355