InnateDB Protein
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IDBP-241225.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCL8
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Protein Name
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chemokine (C-C motif) ligand 8
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Synonyms
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HC14; MCP-2; MCP2; SCYA10; SCYA8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378118
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InnateDB Gene
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IDBG-40686 (CCL8)
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Protein Structure
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Function |
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269PubMed:9558113}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001811
Chemokine interleukin-8-like domain
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PFAM |
PF00048
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PRINTS |
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PIRSF |
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SMART |
SM00199
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TIGRFAMs |
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Modification |
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SwissProt |
P80075
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PhosphoSite |
PhosphoSite-
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TrEMBL |
H0UIC7
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UniProt Splice Variant |
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Entrez Gene |
6355
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UniGene |
Hs.713001
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RefSeq |
NP_005614
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HUGO |
HGNC:10635
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OMIM |
602283
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CCDS |
CCDS11280
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HPRD |
03791
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IMGT |
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EMBL |
BC126242
CH471147
X99886
Y10802
Y16645
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GenPept |
AAI26243
CAA68168
CAA71760
CAA76341
EAW80207
EAW80208
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