Version 5.4
Homo sapiens Gene: BRE
Summary
InnateDB Gene IDBG-40729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRE
Gene Name brain and reproductive organ-expressed (TNFRSF1A modulator)
Synonyms BRCC4; BRCC45
Species Homo sapiens
Ensembl Gene ENSG00000158019
Encoded Proteins
IDBP-40731
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-40733
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-40735
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-40737
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-40739
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-40745
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-370471
brain and reproductive organ-expressed (TNFRSF1A modulator)
IDBP-810644
brain and reproductive organ-expressed (TNFRSF1A modulator)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27889941-28338901
Strand Forward strand
Band p23.2
Transcripts
ENST00000379632 ENSP00000368953
ENST00000342045 ENSP00000339371
ENST00000344773 ENSP00000343412
ENST00000379629 ENSP00000368950
ENST00000379624 ENSP00000368945
ENST00000361704 ENSP00000354699
ENST00000436924 ENSP00000392345
ENST00000492702
ENST00000496951
ENST00000603461
ENST00000604932 ENSP00000474342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000268 peroxisome targeting sequence binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
Biological Process
GO:0006302 double-strand break repair
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0010212 response to ionizing radiation
GO:0016568 chromatin modification
GO:0031572 G2 DNA damage checkpoint
GO:0045739 positive regulation of DNA repair
Cellular Component
GO:0000152 nuclear ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052139
View Gene Order
ENSBTAG00000031335
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.258314 Hs.613679 Hs.741572
RefSeq NM_001261840 NM_004899 NM_199191 NM_199192 NM_199193 NM_199194
HUGO
OMIM
CCDS CCDS1763 CCDS1764 CCDS1765
HPRD 08498
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca