InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRE

Summary

InnateDB Protein

IDBP-40733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRE

Protein Name

brain and reproductive organ-expressed (TNFRSF1A modulator)

Synonyms

BRCC4; BRCC45;

Species

Homo sapiens

Ensembl Protein

ENSP00000339371

InnateDB Gene

IDBG-40729 (BRE)

Protein Structure

UniProt Annotation

Function

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect. {ECO:0000269PubMed:14636569, ECO:0000269PubMed:15465831, ECO:0000269PubMed:19261748, ECO:0000269PubMed:19261749}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

Disease Associations

Tissue Specificity

Expressed in all cell lines examined. Highly expressed in placenta. {ECO:0000269PubMed:11676476}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000268	peroxisome targeting sequence binding
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006302	double-strand break repair
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007165	signal transduction
GO:0010212	response to ionizing radiation
GO:0016568	chromatin modification
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair