Version 5.4
Homo sapiens Gene: UGT1A1
Summary
InnateDB Gene IDBG-407489.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT1A1
Gene Name UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000241635
Encoded Proteins
IDBP-83556
UDP glucuronosyltransferase 1 family, polypeptide A1
IDBP-83572
UDP glucuronosyltransferase 1 family, polypeptide A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:233760248-233773299
Strand Forward strand
Band q37.1
Transcripts
ENST00000360418 ENSP00000353593
ENST00000305208 ENSP00000304845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0004857 enzyme inhibitor activity
GO:0005496 steroid binding
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001889 liver development
GO:0005975 carbohydrate metabolic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006789 bilirubin conjugation
GO:0006805 xenobiotic metabolic process
GO:0006953 acute-phase response
GO:0007584 response to nutrient
GO:0007586 digestion
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0017144 drug metabolic process
GO:0030259 lipid glycosylation
GO:0031100 organ regeneration
GO:0032496 response to lipopolysaccharide
GO:0032870 cellular response to hormone stimulus
GO:0042167 heme catabolic process
GO:0042493 response to drug
GO:0042573 retinoic acid metabolic process
GO:0042594 response to starvation
GO:0043086 negative regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0045939 negative regulation of steroid metabolic process
GO:0046483 heterocycle metabolic process
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
GO:0051552 flavone metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:0070980 biphenyl catabolic process
GO:0071361 cellular response to ethanol
GO:0071385 cellular response to glucocorticoid stimulus
GO:2001030 negative regulation of cellular glucuronidation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070069 cytochrome complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000089960
View Gene Order
ENSBTAG00000026181
Not yet available
Pathways
NETPATH
REACTOME
REACT_22297
Heme degradation pathway
REACT_6784
Glucuronidation pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
hsa00982
Drug metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.554822 Hs.643992
RefSeq NM_000463
HUGO
OMIM
CCDS CCDS2510
HPRD 08933
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca