InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.63686

Summary

InnateDB Gene

IDBG-641949.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.63686

Gene Name

UDP-glucuronosyltransferase 1-6 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026181

Encoded Proteins

IDBP-694358

UDP-glucuronosyltransferase 1-6

IDBP-694360

UDP-glucuronosyltransferase 1-6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241635:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:113907720-114031371

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006163	ENSBTAP00000006163
ENSBTAT00000037089	ENSBTAP00000036928

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004857	enzyme inhibitor activity
GO:0005496	steroid binding
GO:0015020	glucuronosyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0043086	negative regulation of catalytic activity
GO:0051552	flavone metabolic process
GO:0052695	cellular glucuronidation
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation
GO:2001030	negative regulation of cellular glucuronidation