Version 5.4
Homo sapiens Gene: LEFTY1
Summary
InnateDB Gene IDBG-407508.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEFTY1
Gene Name left-right determination factor 1
Synonyms LEFTB; LEFTYB
Species Homo sapiens
Ensembl Gene ENSG00000243709
Encoded Proteins
IDBP-106979
left-right determination factor 1
IDBP-807428
left-right determination factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225886282-225911382
Strand Reverse strand
Band q42.12
Transcripts
ENST00000272134 ENSP00000272134
ENST00000492457 ENSP00000479837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003007 heart morphogenesis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007368 determination of left/right symmetry
GO:0016049 cell growth
GO:0040007 growth
Cellular Component
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_111059
Regulation of signaling by NODAL pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O75610
TrEMBL
UniProt Splice Variant
Entrez Gene 10637
UniGene
RefSeq NM_020997
HUGO HGNC:6552
OMIM 603037
CCDS CCDS1548
HPRD 09116
IMGT
EMBL AF081504 AF081505 AF081506 AF081507 AF081512 AK222714 AK313115 AL117348 AY358873 BC027883
GenPept AAC33967 AAD48144 AAH27883 AAQ89232 BAD96434 BAG35937 CAI21799
RNA Seq Atlas 10637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca