InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LEFTY1

Summary

InnateDB Protein

IDBP-106979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEFTY1

Protein Name

left-right determination factor 1

Synonyms

LEFTB; LEFTYB;

Species

Homo sapiens

Ensembl Protein

ENSP00000272134

InnateDB Gene

IDBG-407508 (LEFTY1)

Protein Structure

UniProt Annotation

Function

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005160	transforming growth factor beta receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003007	heart morphogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0016049	cell growth
GO:0040007	growth

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003942 Left- Right determination factor
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01427

PIRSF

PIRSF037402

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References