Version 5.4
Homo sapiens Gene: TWF2
Summary
InnateDB Gene IDBG-407859.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWF2
Gene Name twinfilin, actin-binding protein, homolog 2 (Drosophila)
Synonyms A6r; A6RP; PTK9L
Species Homo sapiens
Ensembl Gene ENSG00000247596
Encoded Proteins
IDBP-38316
twinfilin, actin-binding protein, homolog 2 (Drosophila)
IDBP-484572
twinfilin, actin-binding protein, homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52228610-52239260
Strand Reverse strand
Band p21.2
Transcripts
ENST00000305533 ENSP00000303908
ENST00000499914 ENSP00000426464
ENST00000472755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0010976 positive regulation of neuron projection development
GO:0030030 cell projection organization
GO:0030837 negative regulation of actin filament polymerization
GO:0032532 regulation of microvillus length
GO:0032956 regulation of actin cytoskeleton organization
GO:0042989 sequestering of actin monomers
GO:0045773 positive regulation of axon extension
GO:0051016 barbed-end actin filament capping
GO:0071300 cellular response to retinoic acid
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030016 myofibril
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0032420 stereocilium
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000023277
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436439
RefSeq NM_007284
HUGO
OMIM
CCDS CCDS2849
HPRD 08464
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca