InnateDB Protein
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IDBP-38316.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TWF2
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Protein Name
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twinfilin, actin-binding protein, homolog 2 (Drosophila)
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Synonyms
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A6r; A6RP; PTK9L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303908
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InnateDB Gene
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IDBG-407859 (TWF2)
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Protein Structure
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Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed (at protein level). {ECO:0000269PubMed:10406962}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
53
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0010592
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positive regulation of lamellipodium assembly
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GO:0010976
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positive regulation of neuron projection development
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GO:0030030
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cell projection organization
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GO:0030837
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negative regulation of actin filament polymerization
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GO:0032532
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regulation of microvillus length
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GO:0032956
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regulation of actin cytoskeleton organization
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GO:0042989
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sequestering of actin monomers
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GO:0045773
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positive regulation of axon extension
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GO:0051016
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barbed-end actin filament capping
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GO:0071300
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cellular response to retinoic acid
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GO:0071363
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cellular response to growth factor stimulus
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Cellular Component |
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PDB ID |
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
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PFAM |
PF00241
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PRINTS |
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IBS0
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PhosphoSite |
PhosphoSite-Q6IBS0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11344
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UniGene |
Hs.436439
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RefSeq |
NP_009215
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HUGO |
HGNC:9621
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OMIM |
607433
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CCDS |
CCDS2849
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HPRD |
08464
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IMGT |
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EMBL |
AF109365
AL136773
BC000327
BC003161
BC016452
CR456732
CR533520
Y17169
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GenPept |
AAH00327
AAH03161
AAH16452
AAQ13513
CAB38055
CAB66707
CAG33013
CAG38551
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