Version 5.4
Homo sapiens Gene: CD82
Summary
InnateDB Gene IDBG-40873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD82
Gene Name CD82 molecule
Synonyms 4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6; TSPAN27
Species Homo sapiens
Ensembl Gene ENSG00000085117
Encoded Proteins
IDBP-40875
CD82 molecule
IDBP-40877
CD82 molecule
IDBP-596441
CD82 molecule
IDBP-596434
CD82 molecule
IDBP-588185
CD82 molecule
IDBP-598193
CD82 molecule
IDBP-594254
CD82 molecule
IDBP-599074
CD82 molecule
IDBP-595420
CD82 molecule
IDBP-601036
CD82 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:44564427-44620363
Strand Forward strand
Band p11.2
Transcripts
ENST00000227155 ENSP00000227155
ENST00000342935 ENSP00000339686
ENST00000526958 ENSP00000435682
ENST00000532544 ENSP00000431767
ENST00000529277
ENST00000525210 ENSP00000435661
ENST00000525898
ENST00000527737 ENSP00000433151
ENST00000524704 ENSP00000436403
ENST00000525813 ENSP00000433804
ENST00000529853
ENST00000530601 ENSP00000433788
ENST00000530931
ENST00000524750 ENSP00000433036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 23 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027215
View Gene Order
ENSBTAG00000031252
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527778
RefSeq NM_001024844 NM_002231 XM_006718222 XM_006718223
HUGO
OMIM
CCDS CCDS31469 CCDS7909
HPRD 09004
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca