Version 5.4
Homo sapiens Gene: ARFGAP3
Summary
InnateDB Gene IDBG-408807.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGAP3
Gene Name ADP-ribosylation factor GTPase activating protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000242247
Encoded Proteins
IDBP-10289
ADP-ribosylation factor GTPase activating protein 3
IDBP-379045
ADP-ribosylation factor GTPase activating protein 3
IDBP-379064
ADP-ribosylation factor GTPase activating protein 3
IDBP-379065
ADP-ribosylation factor GTPase activating protein 3
IDBP-379070
ADP-ribosylation factor GTPase activating protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42796502-42858106
Strand Reverse strand
Band q13.2
Transcripts
ENST00000263245 ENSP00000263245
ENST00000437119 ENSP00000388791
ENST00000453516 ENSP00000403995
ENST00000454099 ENSP00000403520
ENST00000435208 ENSP00000407734
ENST00000493606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0009306 protein secretion
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054277
View Gene Order
ENSBTAG00000001057
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.685225 Hs.722463
RefSeq NM_001142293 NM_014570
HUGO
OMIM
CCDS CCDS14042 CCDS46722
HPRD 06444
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca