Version 5.4
Homo sapiens Protein: ARFGAP3
Summary
InnateDB Protein IDBP-10289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGAP3
Protein Name ADP-ribosylation factor GTPase activating protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263245
InnateDB Gene IDBG-408807 (ARFGAP3)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269PubMed:11172815}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17760859}. Golgi apparatus membrane {ECO:0000269PubMed:17760859}; Peripheral membrane protein {ECO:0000269PubMed:17760859}; Cytoplasmic side {ECO:0000269PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. {ECO:0000269PubMed:10704287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0008565 protein transporter activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006886 intracellular protein transport
GO:0009306 protein secretion
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP61
PhosphoSite PhosphoSite-Q9NP61
TrEMBL A0A024R4U0
UniProt Splice Variant
Entrez Gene 26286
UniGene Hs.722463
RefSeq NP_055385
HUGO HGNC:661
OMIM 612439
CCDS CCDS14042
HPRD 06444
IMGT
EMBL AF111847 AK002083 AK022768 AL049757 AL049758 AL137598 AL159143 BC005122 CH471138 CR456382
GenPept AAF40310 AAH05122 BAA92076 BAB14236 CAB70834 CAB76901 CAG30268 CAI20950 CAI21510 EAW73275 EAW73276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca