Version 5.4
Homo sapiens Gene: TXNDC5
Summary
InnateDB Gene IDBG-408882.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC5
Gene Name thioredoxin domain containing 5 (endoplasmic reticulum)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000239264
Encoded Proteins
IDBP-60067
thioredoxin domain containing 5 (endoplasmic reticulum)
IDBP-483356
thioredoxin domain containing 5 (endoplasmic reticulum)
IDBP-593599
thioredoxin domain containing 5 (endoplasmic reticulum)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:7881517-7910814
Strand Reverse strand
Band p24.3
Transcripts
ENST00000379757 ENSP00000369081
ENST00000460138
ENST00000473453 ENSP00000420784
ENST00000475802
ENST00000469459
ENST00000539054 ENSP00000442453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0006457 protein folding
GO:0006892 post-Golgi vesicle-mediated transport
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0045454 cell redox homeostasis
GO:0061024 membrane organization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000038991
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001145549 NM_030810
HUGO
OMIM
CCDS CCDS4505 CCDS47369
HPRD 18249
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca