Version 5.4
Homo sapiens Protein: TXNDC5
Summary
InnateDB Protein IDBP-483356.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC5
Protein Name thioredoxin domain containing 5 (endoplasmic reticulum)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000420784
InnateDB Gene IDBG-408882 (TXNDC5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0006457 protein folding
GO:0006892 post-Golgi vesicle-mediated transport
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0045454 cell redox homeostasis
GO:0061024 membrane organization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005788 Disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBS9
PhosphoSite PhosphoSite-Q8NBS9
TrEMBL A0A024QZV0
UniProt Splice Variant
Entrez Gene 81567
UniGene
RefSeq NP_001139021
HUGO HGNC:21073
OMIM
CCDS CCDS47369
HPRD 18249
IMGT
EMBL AJ440721 AK075291 AK315598 AL023694 AL096800 AL133541 AL834423 AY358646 BC001199 CH471087
GenPept AAH01199 AAQ89009 BAC11526 BAG37969 CAD29430 CAD39084 CAI19473 EAW55221 EAW55222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca