Version 5.4
| Homo sapiens Gene: PCDHGA6 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-408885.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PCDHGA6 | ||||||||||||||||||
| Gene Name | protocadherin gamma subfamily A, 6 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000253731 | ||||||||||||||||||
| Encoded Proteins |
protocadherin gamma subfamily A, 6
protocadherin gamma subfamily A, 6
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 5:141373914-141512979 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q31.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9Y5G7 | ||||||||||||||||||
| TrEMBL | Q9BT64 Q9UKW1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 56109 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_018919 NM_032086 | ||||||||||||||||||
| HUGO | HGNC:8704 | ||||||||||||||||||
| OMIM | 606293 | ||||||||||||||||||
| CCDS | CCDS54926 CCDS75335 | ||||||||||||||||||
| HPRD | 09383 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF119570 AF152326 AF152513 BC004321 BC136702 BC136703 BC146651 CH471062 | ||||||||||||||||||
| GenPept | AAD43720 AAD43773 AAF03087 AAH04321 AAI36703 AAI36704 AAI46652 EAW61929 EAW61931 | ||||||||||||||||||
| RNA Seq Atlas | 56109 | ||||||||||||||||||