Version 5.4
Homo sapiens Gene: MRPS17
Summary
InnateDB Gene IDBG-409052.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS17
Gene Name mitochondrial ribosomal protein S17
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000239789
Encoded Proteins
IDBP-17315
mitochondrial ribosomal protein S17
IDBP-375913
mitochondrial ribosomal protein S17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:55951819-55956501
Strand Forward strand
Band p11.2
Transcripts
ENST00000285298 ENSP00000285298
ENST00000443449 ENSP00000401349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034211
View Gene Order
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
REACT_267602
Mitochondrial translation termination pathway
REACT_267677
Mitochondrial translation elongation pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.44298 Hs.710695
RefSeq NM_015969
HUGO
OMIM
CCDS CCDS5520
HPRD 14779
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca