InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHST4

Summary

InnateDB Gene

IDBG-40958.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST4

Gene Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

Synonyms

GlcNAc6ST2; GST3; HECGLCNAC6ST; LSST

Species

Homo sapiens

Ensembl Gene

ENSG00000140835

Encoded Proteins

IDBP-40960

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

IDBP-590489

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3\'phosphoadenosine 5\'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5\' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:71525233-71538746

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000338482	ENSP00000341206
ENST00000539698	ENSP00000441204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006477	protein sulfation
GO:0006790	sulfur compound metabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0050901	leukocyte tethering or rolling

Cellular Component

GO:0000139	Golgi membrane
GO:0005802	trans-Golgi network
GO:0016021	integral component of membrane
GO:0031228	intrinsic component of Golgi membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035930

View Gene Order

ENSBTAG00000016968

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00533

Glycosaminoglycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

Q8NCG5

TrEMBL

UniProt Splice Variant

Entrez Gene

10164

UniGene

Hs.251383

RefSeq

NM_005769 NM_001166395

HUGO

HGNC:1972

OMIM

CCDS

CCDS10902

HPRD

07477

IMGT

EMBL

AF131235 AF149783 AF280088 AK074746 BC035282

GenPept

AAD33015 AAG48246 AAH35282 AAK48417 BAC11177

RNA Seq Atlas

10164