Version 5.4
Mus musculus Gene: Chst4
Summary
InnateDB Gene IDBG-191695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chst4
Gene Name carbohydrate (chondroitin 6/keratan) sulfotransferase 4
Synonyms Gn6st-2; GST-3; HEC-GlcNAc6ST
Species Mus musculus
Ensembl Gene ENSMUSG00000035930
Encoded Proteins
IDBP-262851
carbohydrate (chondroitin 6/keratan) sulfotransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140835:
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3\'phosphoadenosine 5\'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5\' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:110029075-110039334
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000109222 ENSMUSP00000104845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006477 protein sulfation
GO:0006790 sulfur compound metabolic process
GO:0006954 inflammatory response
GO:0050901 leukocyte tethering or rolling
Cellular Component
GO:0000139 Golgi membrane
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140835
View Gene Order
ENSBTAG00000016968
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00533
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00533
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.89207
RefSeq NM_011998 XM_006531043 XM_006531044 XM_006531045
OMIM
CCDS CCDS22659
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca