InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL3

Summary

InnateDB Gene

IDBG-41115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL3

Gene Name

interleukin 3 (colony-stimulating factor, multiple)

Synonyms

IL-3; MCGF; MULTI-CSF

Species

Homo sapiens

Ensembl Gene

ENSG00000164399

Encoded Proteins

IDBP-41119

interleukin 3 (colony-stimulating factor, multiple)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:132060529-132063204

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000296870

ENSP00000296870

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	5 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005135	interleukin-3 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0035162	embryonic hemopoiesis
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045740	positive regulation of DNA replication
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation