InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL3

Summary

InnateDB Protein

IDBP-41119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL3

Protein Name

interleukin 3 (colony-stimulating factor, multiple)

Synonyms

IL-3; MCGF; MULTI-CSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000296870

InnateDB Gene

IDBG-41115 (IL3)

Protein Structure

UniProt Annotation

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Activated T-cells, mast cells, natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	5 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005135	interleukin-3 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0035162	embryonic hemopoiesis
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045740	positive regulation of DNA replication
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation