Version 5.4
Homo sapiens Gene: FOXH1
Summary
InnateDB Gene IDBG-41162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXH1
Gene Name forkhead box H1
Synonyms FAST-1; FAST1
Species Homo sapiens
Ensembl Gene ENSG00000160973
Encoded Proteins
IDBP-41166
forkhead box H1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144473412-144476335
Strand Reverse strand
Band q24.3
Transcripts
ENST00000377317 ENSP00000366534
ENST00000525197
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0035326 enhancer binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0050681 androgen receptor binding
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001947 heart looping
GO:0003139 secondary heart field specification
GO:0003151 outflow tract morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007368 determination of left/right symmetry
GO:0009952 anterior/posterior pattern specification
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035909 aorta morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048318 axial mesoderm development
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000824 negative regulation of androgen receptor activity
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0032444 activin responsive factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033837
View Gene Order
ENSBTAG00000004761
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_150238
Signaling by Activin pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708365
RefSeq NM_003923
HUGO
OMIM
CCDS CCDS6428
HPRD 04689
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca