InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXH1

Summary

InnateDB Protein

IDBP-41166.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXH1

Protein Name

forkhead box H1

Synonyms

FAST-1; FAST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000366534

InnateDB Gene

IDBG-41162 (FOXH1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269PubMed:9702198}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9702198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0035326	enhancer binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046332	SMAD binding
GO:0050681	androgen receptor binding
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001947	heart looping
GO:0003139	secondary heart field specification
GO:0003151	outflow tract morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007368	determination of left/right symmetry
GO:0009952	anterior/posterior pattern specification
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035909	aorta morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048318	axial mesoderm development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000824	negative regulation of androgen receptor activity