Version 5.4
Homo sapiens Gene: CRY2
Summary
InnateDB Gene IDBG-41167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRY2
Gene Name cryptochrome 2 (photolyase-like)
Synonyms HCRY2; PHLL2
Species Homo sapiens
Ensembl Gene ENSG00000121671
Encoded Proteins
IDBP-372142
cryptochrome 2 (photolyase-like)
IDBP-372143
cryptochrome 2 (photolyase-like)
IDBP-806785
cryptochrome circadian clock 2
IDBP-806790
cryptochrome circadian clock 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:45847118-45883248
Strand Forward strand
Band p11.2
Transcripts
ENST00000417225 ENSP00000397419
ENST00000443527 ENSP00000406751
ENST00000496571
ENST00000473199
ENST00000495237
ENST00000496667
ENST00000488962
ENST00000532390
ENST00000533779
ENST00000525110
ENST00000616080 ENSP00000484684
ENST00000616623 ENSP00000478187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000989 transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0003913 DNA photolyase activity
GO:0005515 protein binding
GO:0009882 blue light photoreceptor activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0035257 nuclear hormone receptor binding
GO:0043130 ubiquitin binding
GO:0071949 FAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006606 protein import into nucleus
GO:0007623 circadian rhythm
GO:0009785 blue light signaling pathway
GO:0018298 protein-chromophore linkage
GO:0019915 lipid storage
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000118 regulation of sodium-dependent phosphate transport
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
GO:2000850 negative regulation of glucocorticoid secretion
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068742
View Gene Order
ENSBTAG00000021223
Not yet available
Pathways
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001127457 NM_021117
HUGO
OMIM
CCDS CCDS44576 CCDS7915
HPRD 07226
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca