Version 5.4
Homo sapiens Gene: NOVA1
Summary
InnateDB Gene IDBG-4123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOVA1
Gene Name neuro-oncological ventral antigen 1
Synonyms Nova-1
Species Homo sapiens
Ensembl Gene ENSG00000139910
Encoded Proteins
IDBP-4127
neuro-oncological ventral antigen 1
IDBP-4129
neuro-oncological ventral antigen 1
IDBP-364776
neuro-oncological ventral antigen 1
IDBP-591817
neuro-oncological ventral antigen 1
IDBP-587549
neuro-oncological ventral antigen 1
IDBP-595597
neuro-oncological ventral antigen 1
IDBP-593448
neuro-oncological ventral antigen 1
IDBP-598062
neuro-oncological ventral antigen 1
IDBP-591219
neuro-oncological ventral antigen 1
IDBP-597438
neuro-oncological ventral antigen 1
IDBP-706809
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:26443093-26597754
Strand Reverse strand
Band q12
Transcripts
ENST00000347476 ENSP00000299472
ENST00000344429 ENSP00000342387
ENST00000449198 ENSP00000408914
ENST00000465357 ENSP00000447391
ENST00000483536 ENSP00000448956
ENST00000539517 ENSP00000438875
ENST00000546546 ENSP00000448144
ENST00000549146 ENSP00000449113
ENST00000549571 ENSP00000449185
ENST00000547619 ENSP00000448157
ENST00000551754
ENST00000547415
ENST00000574031 ENSP00000459545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 122 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 122 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008380 RNA splicing
GO:0051252 regulation of RNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021047
View Gene Order
ENSBTAG00000002170
Not yet available
Cross-References
SwissProt P51513
TrEMBL G8JLA5
UniProt Splice Variant
Entrez Gene 4857
UniGene Hs.31588 Hs.607686 Hs.609716 Hs.667349
RefSeq NM_006489 NM_002515 NM_006491
HUGO HGNC:7886
OMIM 602157
CCDS CCDS32060 CCDS32061 CCDS9635
HPRD 03693
IMGT
EMBL AK289639 AK291022 AL079343 AL132716 BC075038 BC075039 CH471078 U04840 Z70771
GenPept AAA16022 AAH75038 AAH75039 BAF82328 BAF83711 CAA94810 EAW65990 EAW65991 EAW65992 EAW65993 EAW65995
RNA Seq Atlas 4857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca